Anticancer agent 127

• 常用名: Anticancer agent 127
• 英文名: Anticancer agent 127
• CAS号: 2410953-19-2
• 分子量: 552.66
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₇FN₄O₆S
• 熔点: N/A
• 闪点: N/A

Anticancer agent 127用途

抗癌剂127(142D6)是一种IAP抑制剂,其共价靶向XIAP、cIAP1和cIAP2的BIR3结构域。抗癌剂127靶向XIAP、cIAP1和cIAP2的BIR3结构域,IC50分别为12nM、14nM和9nM。抗癌剂127具有抗癌作用[1]。

Anticancer agent 127名称

• 英文名: Anticancer agent 127

Anticancer agent 127生物活性

• 描述: 抗癌剂127(142D6)是一种IAP抑制剂,其共价靶向XIAP、cIAP1和cIAP2的BIR3结构域。抗癌剂127靶向XIAP、cIAP1和cIAP2的BIR3结构域,IC50分别为12nM、14nM和9nM。抗癌剂127具有抗癌作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> IAP
• 靶点实验:

  IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)[1]

• 参考文献:

  [1]. Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.

Anticancer agent 127物理化学性质

• 分子式: C₂₆H₃₇FN₄O₆S
• 分子量: 552.66

Anticancer agent 127靶点实验

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实验名称：Binding affinity to N-terminal His-tagged human XIAP-BIR3 (253 to 347 residues) expre... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL4416029

实验名称：Oral bioavailability in Balb/c mouse at 30 mg/kg measured upto 24 hrs by LC/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5343721

实验名称：Bioavailability in Balb/c mouse at 30 mg/kg, ip measured upto 24 hrs by LC/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5343722

实验名称：Binding affinity to human XIAP BIR3 domain K299A mutant at 10 uM incubated for 2 hrs ... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343717

实验名称：Binding affinity to human XIAP BIR3 domain (253 to 347 residues) expressed in Escheri... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343715

实验名称：Binding affinity to human XIAP BIR3 domain K297A mutant at 10 uM incubated for 2 hrs ... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343716

实验名称：Binding affinity to human XIAP BIR3 domain K297A mutant assessed as change in melting... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343713

实验名称：Binding affinity to human XIAP BIR3 domain K299A mutant assessed as change in melting... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343714

实验名称：Displacement of AVPI-biotin from human XIAP BIR3 domain (253 to 347 residues) express... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343711

实验名称：Binding affinity to human XIAP BIR3 domain (253 to 347 residues) expressed in Escheri... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5343712

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