UNC2399

Modify Date: 2024-01-11 01:19:04

UNC2399 structure	Common Name	UNC2399
	CAS Number	2412791-72-9	Molecular Weight	927.17
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₈H₆₆N₁₀O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of UNC2399

UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].

Name	UNC2399

Description	UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	EZH2:17 nM (IC50)
In Vitro	UNC2399 (1-1000 nM) displays high in vitro potency (IC50=17±2 nM) in the EZH2 radioactive biochemical assay[1]. UNC2399 (100 μM) enriches EZH2 from HEK293T cell lysates[1].
References	[1]. Konze KD, et, al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8(6): 1324-34. [2]. Ma A, et, al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.

Molecular Formula	C₄₈H₆₆N₁₀O₇S
Molecular Weight	927.17

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UNC2399
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: UNC2399
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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