2412791-72-9

2412791-72-9 structure

Name: UNC2399
Chemical Name: UNC2399
CAS Number: 2412791-72-9
Molecular Formula: C₆₇H₁₀₄N₁₀O₁₇S
Molecular Weight: 1353.7
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2020-11-28 16:37:04
Modify Date: 2026-07-02 11:33:42
UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].

Name	UNC2399

Description	UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	EZH2:17 nM (IC50)
In Vitro	UNC2399 (1-1000 nM) displays high in vitro potency (IC50=17±2 nM) in the EZH2 radioactive biochemical assay[1]. UNC2399 (100 μM) enriches EZH2 from HEK293T cell lysates[1].
References	[1]. Konze KD, et, al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8(6): 1324-34. [2]. Ma A, et, al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.