PD-1/PD-L1-IN-13

Modify Date: 2024-01-09 17:55:48

PD-1/PD-L1-IN-13 Structure
PD-1/PD-L1-IN-13 structure
Common Name PD-1/PD-L1-IN-13
CAS Number 2413100-40-8 Molecular Weight 726.12
Density N/A Boiling Point N/A
Molecular Formula C36H34ClF2N3O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PD-1/PD-L1-IN-13


PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model[1].

 Names

Name PD-1/PD-L1-IN-13

 PD-1/PD-L1-IN-13 Biological Activity

Description PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model[1].
Related Catalog
References

[1]. Song Z, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. J Med Chem. 2021;64(22):16687-16702.

 Chemical & Physical Properties

Molecular Formula C36H34ClF2N3O9
Molecular Weight 726.12