DC Chemicals Limited
China
Product Name: PD-1/PD-L1-IN-14
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Purity: 98.0%
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Contact: Tony Cao

2499965-12-5

2499965-12-5 structure

2499965-12-5 structure

Name: PD-1/PD-L1-IN-14
Chemical Name: PD-1/PD-L1-IN-14
CAS Number: 2499965-12-5
Molecular Formula: C₂₄H₂₄N₄O₂
Molecular Weight: 400.47
Create Date: 2022-05-20 13:03:53
Modify Date: 2024-01-23 17:23:30
PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].

Name	PD-1/PD-L1-IN-14

Description	PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1 Research Areas >> Inflammation/Immunology
Target	IC50： 27.8 nM (PD-1/PD-L1)[1].
In Vitro	PD-1/PD-L1-IN-14 (compound 17) promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway[1].
References	[1]. Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65(5):3879-3893.

Molecular Formula	C₂₄H₂₄N₄O₂
Molecular Weight	400.47