ADTL-EI1712

Modify Date: 2024-04-18 12:05:02

ADTL-EI1712 Structure
ADTL-EI1712 structure
Common Name ADTL-EI1712
CAS Number 2414916-45-1 Molecular Weight 505.440
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H18Cl2N4O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ADTL-EI1712


ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].

 Names

Name ADTL-EI1712
Synonym More Synonyms

 ADTL-EI1712 Biological Activity

Description ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].
Related Catalog
References

[1]. Wang G, et al. Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types. J Med Chem. 2020 Apr 23;63(8):3976-3995.  

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C22H18Cl2N4O2S2
Molecular Weight 505.440
Exact Mass 504.024811
LogP 4.08
Index of Refraction 1.768

 Synonyms

2-[(2-Chlorobenzoyl)amino]-6-[(2-chlorophenyl)carbamothioyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
Thieno[2,3-c]pyridine-3-carboxamide, 2-[(2-chlorobenzoyl)amino]-6-[[(2-chlorophenyl)amino]thioxomethyl]-4,5,6,7-tetrahydro-
ADTL-EI1712