2414916-45-1

2414916-45-1 structure

Name: ADTL-EI1712
Chemical Name: ADTL-EI1712
CAS Number: 2414916-45-1
Molecular Formula: C₂₂H₁₈Cl₂N₄O₂S₂
Molecular Weight: 505.440
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2021-08-14 23:10:45
Modify Date: 2024-04-18 12:05:02
ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].

Name	ADTL-EI1712
Synonyms	2-[(2-Chlorobenzoyl)amino]-6-[(2-chlorophenyl)carbamothioyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide Thieno[2,3-c]pyridine-3-carboxamide, 2-[(2-chlorobenzoyl)amino]-6-[[(2-chlorophenyl)amino]thioxomethyl]-4,5,6,7-tetrahydro- ADTL-EI1712

Description	ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Wang G, et al. Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types. J Med Chem. 2020 Apr 23;63(8):3976-3995.