c-Met-IN-10

Modify Date: 2024-01-12 18:23:36

c-Met-IN-10 structure	Common Name	c-Met-IN-10
	CAS Number	2415291-03-9	Molecular Weight	516.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₁FN₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of c-Met-IN-10

c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].

Name	c-Met-IN-10

Description	c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	c-Met:16 nM (IC50)
References	[1]. Liu J, et al. Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. Eur J Med Chem. 2020;194:112244.

Molecular Formula	C₂₆H₂₁FN₆O₅
Molecular Weight	516.48

c-Met-IN-10

Use of c-Met-IN-10

Names

c-Met-IN-10 Biological Activity

Chemical & Physical Properties