ZMF-10
Modify Date: 2025-08-28 12:37:22
ZMF-10 structure
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Common Name | ZMF-10 | ||
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| CAS Number | 2415295-37-1 | Molecular Weight | 473.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H17F6N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZMF-10ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer[1]. |
| Name | ZMF-10 |
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| Description | ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer[1]. |
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| Related Catalog | |
| Target |
PAK1:174 nM (IC50) PAK2:1.038 μM (IC50) PAK3:1.372 μM (IC50) |
| In Vitro | ZMF-10 (0-10 μM; 48 hours) exhibits potent antiproliferative activity in a dose-dependent manner[1]. ZMF-10 (20 μM; 24 hours) suppresses the phosphorylation of PAK1 at Ser199 and Thr212[1]. ZMF-10 (10-40 μM; 24 hours) downregulates the expression of ERK, and suppresses the phosphorylation of c-Raf, MEK and ERK; up-regulates the expression of Bax and downregulates the expression of Bcl-2; induces apoptosis in a dose-dependent manner with the increase of early and late apoptotic cell population[1]. ZMF-10 (10-40 μM; 24 hours) inhibits the PI3K-AKT-mTOR signaling with the decreasing phosphorylation of AKT and mTOR; inhibits JNK1/2 and cells migration in MDA-MB-231 cells[1]. Cell Proliferation Assay Cell Line: MDA-MB-231[1] Concentration: 0-10 μM Incubation Time: 48 hours Result: Exhibited potent antiproliferative activity in a dose-dependent manner with an IC50 value of 3.48 μM. Immunofluorescence Cell Line: MDA-MB-231[1] Concentration: 20 μM Incubation Time: 24 hours Result: Suppressed the phosphorylation of PAK1 at Ser199 and Thr212. Western Blot Analysis Cell Line: MDA-MB-231[1] Concentration: 10, 20 and 40 μM Incubation Time: 24 hours Result: Downregulated the expression of ERK, and suppressed the phosphorylation of c-Raf, MEK and ERK; up-regulated the expression of Bax and downregulated the expression of Bcl-2. Apoptosis Analysis Cell Line: MDA-MB-231[1] Concentration: 10, 20 and 40 μM Incubation Time: 24 hours Result: Induced apoptosis in a dose-dependent manner with the increase of early and late apoptotic cell population. |
| References |
| Molecular Formula | C19H17F6N7O |
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| Molecular Weight | 473.37 |