Icosanedioic acid

Modify Date: 2024-01-04 20:14:15

Icosanedioic acid Structure
Icosanedioic acid structure
Common Name Icosanedioic acid
CAS Number 2424-92-2 Molecular Weight 342.513
Density 1.0±0.1 g/cm3 Boiling Point 504.1±23.0 °C at 760 mmHg
Molecular Formula C20H38O4 Melting Point 127ºC
MSDS N/A Flash Point 272.8±19.1 °C

 Use of Icosanedioic acid


Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

 Names

Name eicosanedioic acid
Synonym More Synonyms

 Icosanedioic acid Biological Activity

Description Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 504.1±23.0 °C at 760 mmHg
Melting Point 127ºC
Molecular Formula C20H38O4
Molecular Weight 342.513
Flash Point 272.8±19.1 °C
Exact Mass 342.277008
PSA 74.60000
LogP 7.18
Appearance of Characters Powder
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.474
Water Solubility Slightly soluble in water.

 Safety Information

Safety Phrases S22-S24/25
HS Code 2917190090

 Synthetic Route

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

eicosadioic acid
Icosanedioic acid
1,18-Octadecanedicarboxylic acid
eicosa-1,20-dioic acid
eicosane diacid
1,20-icosanedioic acid
Eicossandioic acid
eicosandioic acid
Eicosanedioic acid
MFCD00059627
octadecane-1,18-dicarboxylic acid
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