Hesperidin methylchalcone

Modify Date: 2024-01-03 14:59:19

Hesperidin methylchalcone structure	Common Name	Hesperidin methylchalcone
	CAS Number	24292-52-2	Molecular Weight	624.587
	Density	1.6±0.1 g/cm3	Boiling Point	953.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₆O₁₅	Melting Point	120 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	309.5±27.8 °C

Use of Hesperidin methylchalcone

Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone inhibits inflammation and pain. Hesperidin methylchalcone exhibits vasoprotective activity[1].

Name	Hesperidin methylchalcone
Synonym	More Synonyms

Description	Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone inhibits inflammation and pain. Hesperidin methylchalcone exhibits vasoprotective activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	NF-κB
References	[1]. Pinho-Ribeiro FA, et al. Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB. Chem Biol Interact. 2015 Feb 25;228:88-99.

Density	1.6±0.1 g/cm3
Boiling Point	953.0±65.0 °C at 760 mmHg
Melting Point	120 °C (dec.)(lit.)
Molecular Formula	C₂₉H₃₆O₁₅
Molecular Weight	624.587
Flash Point	309.5±27.8 °C
Exact Mass	624.205444
PSA	234.29000
LogP	1.86
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.672
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL7085000

CHEMICAL NAME :: Chalcone, 2',3,4'-trihydroxy-4,6'-dimethoxy-, 4'-(6-O-(6-deoxy-alpha-L-mannopyranosyl)- beta-D-glucopyranoside)

CAS REGISTRY NUMBER :: 24292-52-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H36-O15

MOLECULAR WEIGHT :: 624.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: male 10 day(s) pre-mating female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 118,657,1953

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	FL7085000

Assessment of the antineoplastic potential of chalcones in animal models.

Curr. Med. Chem. 20(2) , 186-221, (2013)

One part of chemical space that is endowed with interesting biological properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal stu...

Absorption and elimination of (14C) hesperidin methylchalcone in the rat.

Eur. J. Drug Metab. Pharmacokinet. 6(3) , 171-7, (1981)

Hesperidin methylchalcone resorption and excretion were studied in rats, using 14C-labelling. The level of radioactivity in the blood showed a peak 1-2 hours after oral administration of the labelled ...

Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch.

J. Cardiovasc. Pharmacol. 22(2) , 225-30, (1993)

The Ruscus extract and the flavonoid hesperidine methylchalcone (HMC) are used in treatment of venous insufficiency. In the present study, we used the hamster cheek pouch preparation and investigated ...

2-Propen-1-one, 1-[4-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-

3-Hydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)acryloyl]-5-methoxyphenyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

HESPERIDIN METHYL CHALCONE

HESPERIDIN METHYL CHALCONE*PRACTICAL GRA DE

EINECS 246-128-2

MFCD00010438

Hesperidine Methyl Chalcone

(e)-osyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)