HIV-1 inhibitor-24
Modify Date: 2024-01-12 19:08:55
HIV-1 inhibitor-24 structure
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Common Name | HIV-1 inhibitor-24 | ||
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| CAS Number | 2475658-75-2 | Molecular Weight | 433.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H19N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 inhibitor-24HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1]. |
| Name | HIV-1 inhibitor-24 |
|---|
| Description | HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1]. |
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| Related Catalog | |
| Target |
HIV-1 (WT):1.6 nM (EC50) |
| In Vivo | HIV-1 inhibitor-24 (2 g/kg; IG; single dosage) is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1]. Animal Model: Mice[1] Dosage: 2 g/kg Administration: IG; single dosage Result: Exhibited well tolerance at a dose of 2 g/kg in mice and a significant cardiovascular safety. |
| References |
| Molecular Formula | C26H19N5O2 |
|---|---|
| Molecular Weight | 433.46 |