Pegozafermin

Modify Date: 2025-06-20 14:44:37

Pegozafermin Structure
Pegozafermin structure
Common Name Pegozafermin
CAS Number 2489589-60-6 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pegozafermin


Pegozafermin is a fibroblast growth factor FGF21 (HY-P7012) analog, which is an endogenous metabolic hormone and regulates energy expenditure and glucose and lipid metabolism. Pegozafermin decreases the level of triglyceride (TG), can be used for non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG)[1][2].

 Names

Name Pegozafermin

 Pegozafermin Biological Activity

Description Pegozafermin is a fibroblast growth factor FGF21 (HY-P7012) analog, which is an endogenous metabolic hormone and regulates energy expenditure and glucose and lipid metabolism. Pegozafermin decreases the level of triglyceride (TG), can be used for non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG)[1][2].
Related Catalog
In Vitro High levels of triglyceride (TG) can lead to organ failure, increases risk of cardiovascular disease and acute pancreatitis[1]. Pegozafermin can cause consistent, significant decreases in triglycerides (TG), as well as improvements in hepatic fat and glycemic control[2].
References

[1]. Geng L, et al. The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. Nat Rev Endocrinol. 2020 Nov;16(11):654-667.

[2]. Juan Pablo Frias, et al. BIO89-100 Demonstrated Robust Reductions in Liver Fat and Liver Fat Volume (LFV) by MRI-PDFF, Favorable Tolerability and Potential for Weekly (QW) or Every 2 Weeks (Q2W) Dosing in a Phase 1b/2a Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in NASH. Journal of the Endocrine Society. 2021;5(S1): A5-A6.

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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