PARP1-IN-9

Modify Date: 2024-01-16 07:40:28

PARP1-IN-9 structure	Common Name	PARP1-IN-9
	CAS Number	2494000-71-2	Molecular Weight	359.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₁N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PARP1-IN-9

PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) [1].

Name	PARP1-IN-9

Description	PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP1:30.51 nM (IC50)
In Vitro	PARP1-IN-9 (Compound 5c) shows antiproliferative activity with an IC50 of 3.65 μM against MDA-MB-436 cancer cell line[1].
References	[1]. Eldin A Osman E, et al. Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. Bioorg Chem. 2020 Nov;104:104198.

Molecular Formula	C₁₈H₂₁N₃O₅
Molecular Weight	359.38

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