SLV 320

Modify Date: 2025-08-25 22:01:38

SLV 320 Structure
SLV 320 structure
Common Name SLV 320
CAS Number 251945-92-3 Molecular Weight 308.37800
Density N/A Boiling Point N/A
Molecular Formula C18H20N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SLV 320


Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].

 Names

Name 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
Synonym More Synonyms

 SLV 320 Biological Activity

Description Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
Related Catalog
Target

Ki: 1 nM (adenosine A1 receptor)[1].

References

[1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.

 Chemical & Physical Properties

Molecular Formula C18H20N4O
Molecular Weight 308.37800
Exact Mass 308.16400
PSA 73.83000
LogP 3.41330

 Synonyms

UNII-O1Q96UZ63W
SLV 320
Derenofylline
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