Y-320

Modify Date: 2024-01-02 17:30:22

Y-320 structure	Common Name	Y-320
	CAS Number	288250-47-5	Molecular Weight	505.011
	Density	1.3±0.1 g/cm3	Boiling Point	631.2±55.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₉ClN₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	335.6±31.5 °C

Use of Y-320

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.IC50 value: 20-60 nM (IL-17 production) [1]Target: IL-17Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].

Name	1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
Synonym	More Synonyms

Description	Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.IC50 value: 20-60 nM (IL-17 production) [1]Target: IL-17Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
References	[1]. Ushio H, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.

Density	1.3±0.1 g/cm3
Boiling Point	631.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₉ClN₆O₂
Molecular Weight	505.011
Flash Point	335.6±31.5 °C
Exact Mass	504.204041
PSA	86.42000
LogP	3.58
Appearance of Characters	white solid
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.675
Storage condition	-20℃

1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-

1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide

1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide

Y320

Y-320

DC Chemicals Limited
China
Product Name: Y-320
Price: $450.0/100mg $900.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $133/10mM*1mLinDMSO

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Y-320

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