ataciguat

Modify Date: 2024-01-08 17:50:59

ataciguat structure	Common Name	ataciguat
	CAS Number	254877-67-3	Molecular Weight	576.493
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉Cl₂N₃O₆S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ataciguat

Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3].

Name	ataciguat
Synonym	More Synonyms

Description	Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase
Target	soluble guanylate cyclase[1]
In Vitro	Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings[2]. Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells[2]. Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol[3].
References	[1]. Schindler U, et, al. Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase. Mol Pharmacol. 2006 Apr;69(4):1260-8. [2]. Martinelli AM, et, al. In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation. J Pharm Pharm Sci. 2018;21(1):38-45. [3]. Çakmak E, et, al. Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi. Balkan Med J. 2016 Jul;33(4):453-7.

Density	1.6±0.1 g/cm3
Molecular Formula	C₂₁H₁₉Cl₂N₃O₆S₃
Molecular Weight	576.493
Exact Mass	574.981323
PSA	166.88000
LogP	6.08
Index of Refraction	1.685
Storage condition	2-8°C

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide

Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-

5-Chloro-2-{[(5-chloro-2-thienyl)sulfonyl]amino}-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide

hmr 1766

ataciguat

DC Chemicals Limited
China
Product Name: Ataciguat
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ataciguat
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥2160/10 mM * 1 mL in DMSO

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ataciguat

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