254976-06-2
254976-06-2 structure
- Name: Ataciguat sodium
- Chemical Name: Ataciguat sodium
- CAS Number: 254976-06-2
- Molecular Formula: C21H18Cl2N3NaO6S3
- Molecular Weight: 598.46
- Create Date: 2020-01-11 20:16:02
- Modify Date: 2024-01-12 19:03:04
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Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC; increases cGMP levels in cultured rat aortic smooth muscle cells; induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM; decreases arterial blood pressure in anesthetized pigs. Heart Failure Phase 2 Clinical
| Name | Ataciguat sodium |
|---|
| Description | Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC; increases cGMP levels in cultured rat aortic smooth muscle cells; induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM; decreases arterial blood pressure in anesthetized pigs. Heart Failure Phase 2 Clinical |
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| References | References 1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8. 2. Evgenov OV, et al. Nat Rev Drug Discov. 2006 Sep;5(9):755-68. 3. Schäfer A, et al. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2813-8. 4. Zhou Z, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71. View Related Products by Target Guanylate Cyclase Heart Failure |
| Molecular Formula | C21H18Cl2N3NaO6S3 |
|---|---|
| Molecular Weight | 598.46 |