BJG-03-025

Modify Date: 2024-04-09 12:07:38

BJG-03-025 Structure
BJG-03-025 structure
Common Name BJG-03-025
CAS Number 2553213-90-2 Molecular Weight 563.725
Density N/A Boiling Point N/A
Molecular Formula C28H37N9O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BJG-03-025


BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM.BJG-03-025 demonstrates excellent kinome selectivity was profiled by KINOMEscan screening, PLK1 proved to be a false positive with IC50 of 8.3 uM, 100-300-fold selective for FAK.BJG-03-025 displays antiproliferative activity in three-dimensional (3D)-breast and gastric cancer models and impacts cellular signaling and migration.BJG-03-025 decreased phosphorylated FAK (pFAK Y397) in gastric cancer CDH1–/–RHOAY42C/+ organoid model, decreased aberrant signaling and proliferation of gastric cancer organoids.

 Names

Name BJG-03-025

 BJG-03-025 Biological Activity

Description BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM.BJG-03-025 demonstrates excellent kinome selectivity was profiled by KINOMEscan screening, PLK1 proved to be a false positive with IC50 of 8.3 uM, 100-300-fold selective for FAK.BJG-03-025 displays antiproliferative activity in three-dimensional (3D)-breast and gastric cancer models and impacts cellular signaling and migration.BJG-03-025 decreased phosphorylated FAK (pFAK Y397) in gastric cancer CDH1–/–RHOAY42C/+ organoid model, decreased aberrant signaling and proliferation of gastric cancer organoids.
References 1. Brian J Groendyke, et al. ACS Med Chem Lett. 2020 Dec 14;12(1):30-38.

 Chemical & Physical Properties

Molecular Formula C28H37N9O2S
Molecular Weight 563.725
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