BAY 41-2272

Modify Date: 2025-09-12 13:32:51

BAY 41-2272 structure	Common Name	BAY 41-2272
	CAS Number	256376-24-6	Molecular Weight	360.388
	Density	1.5±0.1 g/cm3	Boiling Point	496.1±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₇FN₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	253.8±28.7 °C

Use of BAY 41-2272

BAY 41-2272 is a soluble guanylate cyclases (sGC) activator.Target: guanylate cyclaseBAY 41-2272 is a recently introduced novel orally available agent that directly stimulates soluble guanylate cyclase (sGC) and sensitizes it to its physiological stimulator, nitric oxide. BAY 41-2272 is a promising new therapeutic agent that goes beyond current therapeutic agents. BAY 41-2272 acts as an arterial vasodilator, resulting in a reduction of MAP and pulmonary artery pressure and a decrease in SVR and renal vascular resistance. BAY 41-2272 reduces pulmonary capillary wedge pressure in the absence of a decrease in right atrial pressure. [2]

Name	5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine
Synonym	More Synonyms

Description	BAY 41-2272 is a soluble guanylate cyclases (sGC) activator.Target: guanylate cyclaseBAY 41-2272 is a recently introduced novel orally available agent that directly stimulates soluble guanylate cyclase (sGC) and sensitizes it to its physiological stimulator, nitric oxide. BAY 41-2272 is a promising new therapeutic agent that goes beyond current therapeutic agents. BAY 41-2272 acts as an arterial vasodilator, resulting in a reduction of MAP and pulmonary artery pressure and a decrease in SVR and renal vascular resistance. BAY 41-2272 reduces pulmonary capillary wedge pressure in the absence of a decrease in right atrial pressure. [2]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase Research Areas >> Inflammation/Immunology
References	[1]. Tuttle TR, et al. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer Lett. 2016 Jan 28;370(2):279-85. [2]. Boerrigter G, et al. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation. 2003 Feb 11;107(5):686-9.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

Research Areas >> Inflammation/Immunology

References

[1]. Tuttle TR, et al. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer Lett. 2016 Jan 28;370(2):279-85.

[2]. Boerrigter G, et al. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation. 2003 Feb 11;107(5):686-9.

Density	1.5±0.1 g/cm3
Boiling Point	496.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₇FN₆
Molecular Weight	360.388
Flash Point	253.8±28.7 °C
Exact Mass	360.149872
PSA	83.24000
LogP	1.99
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.767
Storage condition	-20℃

Precursor 9
CAS#:256376-79-1 2-cyclopropyl-3... CAS#:256376-68-8 1H-Pyrazolo[3,4... CAS#:6542-60-5 Cyclopropylacet... CAS#:51859-98-4 (2-Fluorobenzyl...
CAS#:256376-65-5 1-[(2-fluorophe... CAS#:256504-39-9 Ethyl 5-amino-1... CAS#:256376-62-2 1-(2-Fluorobenz... CAS#:304874-06-4 1-(2-fluorobenz...
CAS#:256376-59-7 1-(2-fluorobenz...
DownStream 0

5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine

5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine

3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine

bay-41-2272

4-pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-

unii-34a162j6wb

BAY 41-2272

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BAY 41-2272
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BAY 41-2272
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: BAY 41-2272
Price: $450.0/100mg $880.0/250mg $1700.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BAY 41-2272
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $106/10mM*1mLinDMSO

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BAY 41-2272

Use of BAY 41-2272

Names

BAY 41-2272 Biological Activity

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Precursor & DownStream

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.