BAY 41-2272

• 常用名: BAY 41-2272
• 英文名: BAY 41-2272
• CAS号: 256376-24-6
• 分子量: 360.388
• 密度: 1.5±0.1 g/cm3
• 沸点: 496.1±45.0 °C at 760 mmHg
• 分子式: C₂₀H₁₇FN₆
• 熔点: N/A
• 闪点: 253.8±28.7 °C

BAY 41-2272用途

BAY 41-2272是一种可溶性鸟苷酸环化酶 (sGC) 活化剂。

BAY 41-2272名称

• 中文名: BAY 41-2272
• 英文名: 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine

BAY 41-2272生物活性

• 描述: BAY 41-2272是一种可溶性鸟苷酸环化酶 (sGC) 活化剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 鸟苷酸环化酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Tuttle TR, et al. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer Lett. 2016 Jan 28;370(2):279-85.

  [2]. Boerrigter G, et al. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation. 2003 Feb 11;107(5):686-9.

BAY 41-2272物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 496.1±45.0 °C at 760 mmHg
• 分子式: C₂₀H₁₇FN₆
• 分子量: 360.388
• 闪点: 253.8±28.7 °C
• 精确质量: 360.149872
• PSA: 83.24000
• LogP: 1.99
• InChIKey: ATOAHNRJAXSBOR-UHFFFAOYSA-N
• SMILES: Nc1nc(-c2nn(Cc3ccccc3F)c3ncccc23)ncc1C1CC1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.767
• 储存条件: -20℃

BAY 41-2272靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS2-PP-HEK293ACE2-f4-mipe-npc

实验名称：VSVG counterscreen qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-VSVG-PP-HEK293ACE2-f4-mipe-npc

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Thermal Shift Assay. Domain: start/stop: M26-R383 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5065589

实验名称：qHTS for Inhibitors of binding or entry into cells for Marburg Virus 来源：NCGC 靶标：gene 4 small orf - Marburg virus External Id：VSVM-OFFLINE

实验名称：qHTS for Inhibitors of binding or entry into cells for Lassa Virus 来源：NCGC 靶标：N/A External Id：VSVL-OFFLINE

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL5060015

共55条，当前第1页，共6页

1

2

3

4

5

BAY 41-2272英文别名

• 5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
• 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine
• 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
• bay-41-2272
• unii-34a162j6wb
• BAY 41-2272