CRA-2059

Modify Date: 2025-08-26 19:17:26

CRA-2059 structure	Common Name	CRA-2059
	CAS Number	256649-36-2	Molecular Weight	750.80
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₄₆N₁₂O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CRA-2059

CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].

Name	CRA-2059

Description	CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Inflammation/Immunology
In Vitro	Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research[1].
References	[1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16(3):407-413. [2]. Selwood T, et al. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem. 2003;384(12):1605-1611.

Molecular Formula	C₃₄H₄₆N₁₂O₈
Molecular Weight	750.80
InChIKey	SDKLWMXBZVGUHI-XPALAHHGSA-N
SMILES	NC(N)=Nc1ccc(CNC(=O)N2CCN(C(=O)OC3COC4C(OC(=O)N5CCN(C(=O)NCc6ccc(N=C(N)N)cc6)CC5)COC34)CC2)cc1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CRA-2059
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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