Cambendazol

Modify Date: 2024-01-06 13:08:35

Cambendazol Structure
Cambendazol structure
 Common Name Cambendazol
CAS Number 26097-80-3 Molecular Weight 302.352
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C14H14N4O2S Melting Point 212-214℃ (ethyl acetate hexane )
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08		 Signal Word Warning

 Use of Cambendazol


Cambendazole is one of the most effective agents for the therapy of human strongyloidiasis and [1].

 Names

Name propan-2-yl N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]carbamate
Synonym More Synonyms

 Cambendazol Biological Activity

Description Cambendazole is one of the most effective agents for the therapy of human strongyloidiasis and [1].
Related Catalog
References

[1]. Bicalho SA, et al. Cambendazole in the treatment of human strongyloidiasis. Am J Trop Med Hyg. 1983 Sep;32(5):1181-3.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 212-214℃ (ethyl acetate hexane )
Molecular Formula C14H14N4O2S
Molecular Weight 302.352
Exact Mass 302.083740
PSA 108.14000
LogP 2.90
Index of Refraction 1.694

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6538000
CHEMICAL NAME :
5-Benzimidazolecarbamic acid, 2-(4-thiazolyl)-, isopropyl ester
CAS REGISTRY NUMBER :
26097-80-3
LAST UPDATED :
199612
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C14-H14-N4-O2-S
MOLECULAR WEIGHT :
302.38
WISWESSER LINE NOTATION :
T56 BM DNJ GMVOY1&1 C- ET5N CSJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
80480 ug/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
60400 ug/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
60800 ug/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
80800 ug/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
348 mg/kg
SEX/DURATION :
female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
348 mg/kg
SEX/DURATION :
female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Mammal - domestic Leukocyte
DOSE/DURATION :
1 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361
Precautionary Statements P281
Hazard Codes Xn
Risk Phrases 63
Safety Phrases 36/37
RIDADR NONH for all modes of transport
RTECS DD6538000

 Synthetic Route

2-thiazol-4-yl-3H-benzoimidazol-5-ylamine structure

2-thiazol-4-yl-...

CAS#:25893-06-5

Isopropyl chloroformate structure

Isopropyl chlor...

CAS#:108-23-6

~%

Cambendazol Structure

Cambendazol

CAS#:26097-80-3

Literature: Merck and Co., Inc. Patent: US3956488 A1, 1976 ;
2-Nitro-1,4-benzenediamine structure

2-Nitro-1,4-ben...

CAS#:5307-14-2

~%

Cambendazol Structure

Cambendazol

CAS#:26097-80-3

Literature: Rajappa, S.; Sreenivasan, R. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 539 - 541
4-isopropoxycarbonylamino-2-nitroaniline structure

4-isopropoxycar...

CAS#:30713-39-4

~%

Cambendazol Structure

Cambendazol

CAS#:26097-80-3

Literature: Rajappa, S.; Sreenivasan, R. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 539 - 541
Thiazole-4-carboxaldehyde structure

Thiazole-4-carb...

CAS#:3364-80-5

N/A structure

N/A

CAS#:35198-67-5

~%

Cambendazol Structure

Cambendazol

CAS#:26097-80-3

Literature: Rajappa, S.; Sreenivasan, R. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 539 - 541

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 Synonyms

Cambenzole
Carbamic acid, N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-, 1-methylethyl ester
Novazole
Isopropyl [2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-yl]carbamate
Equiben
Camvet
(2-thiazol-4-yl-1(3)H-benzoimidazol-5-yl)-carbamic acid isopropyl ester
CBDZ
propan-2-yl [2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-yl]carbamate
cambendazole
Carbamic acid, (2-(4-thiazolyl)-1H-benzimidazol-5-yl)-, 1-methylethyl ester
Isopropyl 2-(4-thiazolyl)-5-benzimidazolecarbamate
NOE [French]
Noviben
Bonlam
[2-(4-thiazolyl)-1H-benzimidazol-5-yl]carbamic acid 1-methylethyl ester
5-isopropoxycarbonylamino-2-(4'-thiazolyl)-benzimidazole
Camdan
Cambendazol
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