Ponceau 4R

Modify Date: 2024-01-02 16:35:46

Ponceau 4R Structure
Ponceau 4R structure
 Common Name Ponceau 4R
CAS Number 2611-82-7 Molecular Weight 604.473
Density N/A Boiling Point N/A
Molecular Formula C20H11N2Na3O10S3 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Ponceau 4R


Ponceau 4R is a synthetic colourant that may be used as a food colouring. onceau 4R is a strawberry red azo dye which can be used in a variety of food products, and is usually synthesized fromaromatic hydrocarbons; it is stable to light, heat, and acid but fades in the presence of ascorbic acid.

 Names

Name Acid Red 18
Synonym More Synonyms

 Ponceau 4R Biological Activity

Description Ponceau 4R is a synthetic colourant that may be used as a food colouring. onceau 4R is a strawberry red azo dye which can be used in a variety of food products, and is usually synthesized fromaromatic hydrocarbons; it is stable to light, heat, and acid but fades in the presence of ascorbic acid.
Related Catalog

 Chemical & Physical Properties

Molecular Formula C20H11N2Na3O10S3
Molecular Weight 604.473
Exact Mass 603.926880
PSA 241.69000
LogP 6.06870

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ6530000
CHEMICAL NAME :
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium salt
CAS REGISTRY NUMBER :
2611-82-7
LAST UPDATED :
199709
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C20-H14-N2-O10-S3.3Na
MOLECULAR WEIGHT :
607.51
WISWESSER LINE NOTATION :
L66J CO HSWO JSWO BNUN- BL66J ESWO &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
143 gm/kg/90D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 mg/m3/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Liver - liver function tests impaired Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
428 gm/kg/64W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
1 gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4494 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 138 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4494 No. of Facilities: 1035 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 8379 (estimated) No. of Female Employees: 2006 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS QJ6530000
HS Code 32041200

 Articles30

More Articles
Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7.

J. Toxicol. Environ. Health A 68(16) , 1431-44, (2005)

Synthetic or natural food dyes are typical xenobiotics, as are drugs and pollutants. After ingestion, part of these dyes may be absorbed and metabolized by phase I and II drug-metabolizing enzymes and...

Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 27(4) , 447-56, (2010)

A double-blind randomized intervention study has previously shown that a significant relationship exists between the consumption of various mixes of seven target additives by children and the onset of...

Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner.

J. Environ. Public Health 2009 , 953952, (2009)

The synthetic food dyes studied were rose bengal (RB), phroxine (PL), amaranth, erythrosine B (ET), allura red, new coccine, acid red (AR), tartrazine, sunset yellow FCF, brilliant blue FCF, and indig...

 Synonyms

EINECS 220-036-2
l-rot4
AcidredR
Brilliant ponceau 5R
foodred7
1578red
Ponceau 4 R
Trisodium 7-hydroxy-8-[(4-sulfonato-1-naphthyl)diazenyl]-1,3-naphthalenedisulfonate
E124
foodred6
COCCINE
MFCD00004084
cochineal red A
AKA102
Food Red No. 102
1,3-Naphthalenedisulfonic acid, 7-hydroxy-8-[2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3)
c.i.185
Red 18
New Coccine
Ponceau 4R
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(1S,4R,5S,6R)-5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile
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866108-64-7
Chemsrc provides Ponceau 4R(CAS#:2611-82-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ponceau 4R are included as well.>> amp version: Ponceau 4R

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