Fmoc-L-Asn(EDA-N3)-OH

Modify Date: 2024-04-02 12:28:28

Fmoc-L-Asn(EDA-N3)-OH Structure
Fmoc-L-Asn(EDA-N3)-OH structure
Common Name Fmoc-L-Asn(EDA-N3)-OH
CAS Number 2616562-74-2 Molecular Weight 423.42
Density N/A Boiling Point N/A
Molecular Formula C21H21N5O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-L-Asn(EDA-N3)-OH


Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II[1].

 Names

Name Fmoc-L-Asn(EDA-N3)-OH

 Fmoc-L-Asn(EDA-N3)-OH Biological Activity

Description Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II[1].
Related Catalog
References

[1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.  

 Chemical & Physical Properties

Molecular Formula C21H21N5O5
Molecular Weight 423.42
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