ARD-1676

Modify Date: 2024-04-09 17:46:10

ARD-1676 Structure
ARD-1676 structure
Common Name ARD-1676
CAS Number 2632305-36-1 Molecular Weight 788.33
Density N/A Boiling Point N/A
Molecular Formula C44H46ClN7O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ARD-1676


ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].

 Names

Name ARD-1676

 ARD-1676 Biological Activity

Description ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].
Related Catalog
References

[1]. Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 8..  

 Chemical & Physical Properties

Molecular Formula C44H46ClN7O5
Molecular Weight 788.33
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