P-Gb-In-1

• 常用名: P-Gb-In-1
• 英文名: P-Gb-In-1
• CAS号: 2632874-49-6
• 分子量: 512.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₂₈N₂O₆
• 熔点: N/A
• 闪点: N/A

P-Gb-In-1用途

P-gb-IN-1(化合物Ⅲ-8)是2,5-二取代呋喃衍生物,是一种高效、广谱的P-糖蛋白(P-gp)抑制剂。P-gb-IN-1通过抑制P-gp外排而表现出逆转活性。P-gb-IN-1通过与残基Asn 721和Met 986形成氢键相互作用而对P-gp具有强大的亲和力。P-gb-IN-1对MCF-7/ADR细胞具有广谱逆转活性和低毒性[1]。

P-Gb-In-1名称

• 英文名: P-gb-IN-1

P-Gb-In-1生物活性

• 描述: P-gb-IN-1(化合物Ⅲ-8)是2,5-二取代呋喃衍生物,是一种高效、广谱的P-糖蛋白(P-gp)抑制剂。P-gb-IN-1通过抑制P-gp外排而表现出逆转活性。P-gb-IN-1通过与残基Asn 721和Met 986形成氢键相互作用而对P-gp具有强大的亲和力。P-gb-IN-1对MCF-7/ADR细胞具有广谱逆转活性和低毒性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 跨膜转运 >> P-糖蛋白
• 参考文献:

  [1]. Zhikun Yang, et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur J Med Chem. 2023 Sep 5;257:115462.

P-Gb-In-1物理化学性质

• 分子式: C₃₀H₂₈N₂O₆
• 分子量: 512.55
• InChIKey: FAYQCAXJNWNFQJ-UHFFFAOYSA-N
• SMILES: COc1ccc(C(=O)Nc2ccc(-c3ccc(C(=O)N4CCc5cc(OC)c(OC)cc5C4)o3)cc2)cc1

P-Gb-In-1靶点实验

查看更多实验

实验名称：Cytotoxicity against human MCF7ADR cells assessed as doxorubicin IC50 at 5 uM incubat... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621192

实验名称：Cytotoxicity against human MCF7ADR cells assessed as cell survival rate at 5 uM incub... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621193

实验名称：Cytotoxicity against human MCF7 cells assessed as cell survival rate at 5 uM incubate... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5621195

实验名称：Reversal activity against doxorubicin-mediated resistance in human MCF7ADR cells asse... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621196

实验名称：Reversal activity against doxorubicin-mediated resistance in human MCF7ADR cells asse... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621197

实验名称：Reversal activity against doxorubicin-mediated resistance in human MCF7ADR cells asse... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621201

实验名称：Reversal activity against doxorubicin-mediated resistance in human MCF7ADR cells asse... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621202

实验名称：Reversal activity against paclitaxel-mediated resistance in human MCF7ADR cells asses... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621209

实验名称：Reversal activity against daunorubicin-mediated resistance in human MCF7ADR cells ass... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621210

实验名称：Reversal activity against vincristine-mediated resistance in human MCF7ADR cells asse... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL5621211

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