IZTZ-1

Modify Date: 2024-02-04 10:15:28

IZTZ-1 Structure
IZTZ-1 structure
Common Name IZTZ-1
CAS Number 2636771-45-2 Molecular Weight 549.73
Density N/A Boiling Point N/A
Molecular Formula C32H35N7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IZTZ-1


IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].

 Names

Name IZTZ-1

 IZTZ-1 Biological Activity

Description IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].
Related Catalog
In Vivo IZTZ-1 (0-20 mg/kg, IP, once every two days, for 10 days) effectively inhibits tumor growth in a melanoma mouse model[1].
References

[1]. Wu TY, et al. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Jun;99:103866.

 Chemical & Physical Properties

Molecular Formula C32H35N7S
Molecular Weight 549.73
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