GNE-7883
Modify Date: 2024-01-02 12:07:15
GNE-7883 structure
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Common Name | GNE-7883 | ||
|---|---|---|---|---|
| CAS Number | 2648450-42-2 | Molecular Weight | 500.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H29FN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-7883GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1]. |
| Name | GNE-7883 |
|---|
| Description | GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1]. |
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| Related Catalog | |
| Target |
TEAD[1]. |
| References |
| Molecular Formula | C28H29FN6O2 |
|---|---|
| Molecular Weight | 500.57 |
| InChIKey | OMGKSFJZXSXHCA-UHFFFAOYSA-N |
| SMILES | Cc1nccnc1-c1[nH]n2c(=O)cc(-c3ccc(C4CCCCC4)cc3)nc2c1C(=O)N1CC(CF)C1 |