GNE-7883

Modify Date: 2024-01-02 12:07:15

GNE-7883 Structure
GNE-7883 structure
 Common Name GNE-7883
CAS Number 2648450-42-2 Molecular Weight 500.57
Density N/A Boiling Point N/A
Molecular Formula C28H29FN6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GNE-7883


GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1].

 Names

Name GNE-7883

 GNE-7883 Biological Activity

Description GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1].
Related Catalog
Target

TEAD[1].

References

[1]. Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828.  

 Chemical & Physical Properties

Molecular Formula C28H29FN6O2
Molecular Weight 500.57
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Chemsrc provides GNE-7883(CAS#:2648450-42-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of GNE-7883 are included as well.>> amp version: GNE-7883

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