JAK-IN-27 structure
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Common Name | JAK-IN-27 | ||
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CAS Number | 2673176-36-6 | Molecular Weight | 413.42 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C20H21F2N7O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of JAK-IN-27JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1]. |
Name | JAK-IN-27 |
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Description | JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1]. |
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Related Catalog | |
Target |
IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3) |
References |
Molecular Formula | C20H21F2N7O |
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Molecular Weight | 413.42 |