JAK-IN-27

Modify Date: 2024-01-10 12:07:36

JAK-IN-27 Structure
JAK-IN-27 structure
Common Name JAK-IN-27
CAS Number 2673176-36-6 Molecular Weight 413.42
Density N/A Boiling Point N/A
Molecular Formula C20H21F2N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JAK-IN-27


JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].

 Names

Name JAK-IN-27

 JAK-IN-27 Biological Activity

Description JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].
Related Catalog
Target

IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3)

References

[1]. Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.

 Chemical & Physical Properties

Molecular Formula C20H21F2N7O
Molecular Weight 413.42