LY56110

Modify Date: 2024-01-10 10:32:19

LY56110 structure	Common Name	LY56110
	CAS Number	26766-37-0	Molecular Weight	315.20
	Density	1.296g/cm3	Boiling Point	438.3ºC at 760mmHg
	Molecular Formula	C₁₇H₁₂Cl₂N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	251.5ºC

Use of LY56110

LY56110 is an orally active aromatase inhibitor. LY56110 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 2.5 and 11 μΜ, respectively. LY56110 can be used for neurological disorder study[1][2].

Name	5-[bis(4-chlorophenyl)methyl]pyrimidine
Synonym	More Synonyms

Description	LY56110 is an orally active aromatase inhibitor. LY56110 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 2.5 and 11 μΜ, respectively. LY56110 can be used for neurological disorder study[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
References	[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604. [2]. O'Neill LA, et al. Effect of estrogen inhibitors on conceptus estrogen synthesis and development in the gilt. Domest Anim Endocrinol. 1991;8(1):139-153.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

References

[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604.

[2]. O'Neill LA, et al. Effect of estrogen inhibitors on conceptus estrogen synthesis and development in the gilt. Domest Anim Endocrinol. 1991;8(1):139-153.

Density	1.296g/cm3
Boiling Point	438.3ºC at 760mmHg
Molecular Formula	C₁₇H₁₂Cl₂N₂
Molecular Weight	315.20
Flash Point	251.5ºC
Exact Mass	314.03800
PSA	25.78000
LogP	4.96360
Vapour Pressure	1.79E-07mmHg at 25°C
Index of Refraction	1.625

LY43578

CAS#:26766-35-8

~54%

LY56110

CAS#:26766-37-0

Literature: Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; Berven, Bradley; Botero, Adriana; Chaplin, Jason H.; Charman, Susan A.; Chatelain, Eric; Von Geldern, Thomas W.; Kerfoot, Maria; Khong, Andrea; Nguyen, Tien; McManus, Joshua D.; Morizzi, Julia; Ryan, Eileen; Scandale, Ivan; Thompson, R. Andrew; Wang, Sen Z.; White, Karen L. Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4189 - 4204

LY43578

CAS#:26766-35-8

~26%

LY56110

CAS#:26766-37-0

5-[bis(4-chloro...

CAS#:108395-11-5

5-[bis(4-chloro...

CAS#:108395-10-4

Literature: Taylor, Harold M.; Jones, C. David; Davenport, James D.; Hirsch, Kenneth S.; Kress, T.J.; Weaver, Dix Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1359 - 1365

4,4'-Dichlorobe...

CAS#:90-98-2

LY56110

CAS#:26766-37-0

Precursor 2
CAS#:26766-35-8 LY43578 CAS#:90-98-2 4,4'-Dichlorobe...
DownStream 0

5-[(4-chlorophenyl)(4-chlorophenyl)methyl]pyrimidine

5-(Bis(4-chlorophenyl)methyl)pyrimidine

LY56110

Use of LY56110

Names

LY56110 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms