Harringtonine

Modify Date: 2024-01-02 15:08:21

Harringtonine structure	Common Name	Harringtonine
	CAS Number	26833-85-2	Molecular Weight	531.595
	Density	1.4±0.1 g/cm3	Boiling Point	679.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₃₇NO₉	Melting Point	73-75ºC
	MSDS	N/A	Flash Point	364.7±31.5 °C

Use of Harringtonine

Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis.

Name	Harringtonin
Synonym	More Synonyms

Description	Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation[1]. Harringtonine displays potent inhibition of Chikungunya virus infection with an EC50 of 0.24 μM. Harringtonine could inhibit other alphaviruses[2]. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations. The mechanism of the antitumor action of harringtonine is considered to be an effect on protein synthesis and is characterized by breakdown of polysomes to monosomes[3].
Cell Assay	For harringtonine treatment studies with Sindbis virus, BHK21 cells are seeded into 96-well plates and infected with Sindbis virus at an MOI of 1 for 1 h prior to being washed twice with PBS and incubated with various concentrations of harringtonine (0.1 μM, 1 μM, 5 μM, and 10 μM) at 37°C with 5% CO2. Cell supernatants are harvested for plaque assays at 24 h postinfection[2].
References	[1]. Fresno M, et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30. [2]. Kaur P, et al. Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. Antimicrob Agents Chemother. 2013 Jan;57(1):155-67. [3]. Piao YF, et al. Growth inhibition of human myeloid leukemia cells in vitro by harringtonine. Gan To Kagaku Ryoho. 1990 Feb;17(2):281-5.

Density	1.4±0.1 g/cm3
Boiling Point	679.4±55.0 °C at 760 mmHg
Melting Point	73-75ºC
Molecular Formula	C₂₈H₃₇NO₉
Molecular Weight	531.595
Flash Point	364.7±31.5 °C
Exact Mass	531.246826
PSA	123.99000
LogP	2.58
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.610
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FK0250000

CHEMICAL NAME :: Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))-

CAS REGISTRY NUMBER :: 26833-85-2

LAST UPDATED :: 199703

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C28-H37-N-O9

MOLECULAR WEIGHT :: 531.66

WISWESSER LINE NOTATION :: T5 H5 F675 1A T AX IO KO QN BU JHT&&TTJ CO1 DOVXQ1VQ2XQ1&1 T1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4170 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4200 ug/kg/5D-I

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5200 ug/kg/5D-I

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Blood - leukopenia Related to Chronic Data - death

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 200 ug/L

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,173,1986

Hazard Codes	Xi
RIDADR	UN 1544
Packaging Group	II
Hazard Class	6.1(a)

Precursor 3
CAS#:68423-50-7 4-benzyloxy-7,7... CAS#:68423-51-8 (Ξ)-4-benzyloxy... CAS#:24316-19-6 Cephalotaxine
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harringtonine

O-[(2R)-2,5-Dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine

Cephalotaxine, O-[(2R)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methyl-1-oxohexyl]-

Harringtonine (8CI)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Harringtonine
Price: ￥818.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Harringtonine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Harringtonin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: HARRINGTONINE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: $112/10mM*1mLinDMSO

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