VEGFR酪氨酸激酶抑制剂II

• 常用名: VEGFR酪氨酸激酶抑制剂II
• 英文名: N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE
• CAS号: 269390-69-4
• 分子量: 337.80300
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆ClN₃O
• 熔点: N/A
• 闪点: N/A

VEGFR酪氨酸激酶抑制剂II用途

VEGFR-IN-1(化合物3)是一种有效的血管生成抑制剂,KDR、Flt-1、c-Kit、EGF-R和c-Src的IC50分别为0.02、0.18、0.24、7.3和7µM[1]。

VEGFR酪氨酸激酶抑制剂II名称

• 中文名: VEGFR酪氨酸激酶抑制剂II
• 英文名: N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide

VEGFR酪氨酸激酶抑制剂II生物活性

• 描述: VEGFR-IN-1(化合物3)是一种有效的血管生成抑制剂,KDR、Flt-1、c-Kit、EGF-R和c-Src的IC50分别为0.02、0.18、0.24、7.3和7µM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
  信号通路 >> 蛋白酪氨酸激酶 >> c-Kit
• 靶点实验:

  KDR:0.02 μM (IC50)

  Flt-1:0.18 μM (IC50)

  EGFR:0.24 μM (IC50)

• 参考文献:

  [1]. Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13(18):2967-2971.

VEGFR酪氨酸激酶抑制剂II物理化学性质

• 分子式: C₁₉H₁₆ClN₃O
• 分子量: 337.80300
• 精确质量: 337.09800
• PSA: 54.02000
• LogP: 4.74540
• InChIKey: GGPZCOONYBPZEW-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(Cl)cc1)c1ccccc1NCc1ccncc1

VEGFR酪氨酸激酶抑制剂II靶点实验

查看更多实验

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

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VEGFR酪氨酸激酶抑制剂II英文别名

• HMS3229O07
• VEGF Receptor Tyrosine Kinase Inhibitor II