Flupentixol

Modify Date: 2026-06-30 18:51:19

Flupentixol structure	Common Name	Flupentixol
	CAS Number	2709-56-0	Molecular Weight	434.51800
	Density	1.306g/cm3	Boiling Point	554.7ºC at 760mmHg
	Molecular Formula	C₂₃H₂₅F₃N₂OS	Melting Point	N/A
	MSDS	N/A	Flash Point	289.3ºC

Use of Flupentixol

Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].

Summary: Flupenthixol, Chinese name: 三氟噻吨, CAS number: 2709-56-0, molecular formula: C23H25F3N2OS, molecular weight: 434.51800, is a white or gray-white solid. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	flupenthixol
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor D2 Receptor
References	[1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71. [2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.306g/cm3
Boiling Point	554.7ºC at 760mmHg
Molecular Formula	C₂₃H₂₅F₃N₂OS
Molecular Weight	434.51800
Flash Point	289.3ºC
Exact Mass	434.16400
PSA	52.01000
LogP	4.47750
Index of Refraction	1.607
InChIKey	NJMYODHXAKYRHW-UHFFFAOYSA-N
SMILES	OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL9900000

CHEMICAL NAME :: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl )-

CAS REGISTRY NUMBER :: 2709-56-0

LAST UPDATED :: 199507

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H25-F3-N2-O-S

MOLECULAR WEIGHT :: 434.56

WISWESSER LINE NOTATION :: T C666 BS IYJ IU3- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - changes in motor activity (specific assay) Behavioral - coma

REFERENCE :: DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 15,388,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 367 ug/kg/12D-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - muscle weakness Behavioral - headache

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,93,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2121,1977

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	TL9900000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

N-(2-Hydroxyeth...

CAS#:103-76-4

9-prop-2-enylid...

CAS#:28973-34-4

Flupentixol

CAS#:2709-56-0

TRANS-(E)-FLUPE...

CAS#:53772-85-3

Learn More

Literature: LABORATORIO CHIMICO INTERNAZIONALE S.P.A. Patent: WO2005/37820 A1, 2005 ; Location in patent: Page/Page column 8-9 ;

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 2
CAS#:103-76-4 N-(2-Hydroxyeth... CAS#:28973-34-4 9-prop-2-enylid...
DownStream 0

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

n7009

[3H]-(Z)-Flupentixol

siplaril

fluanxol

Flupentiol

fluxanxol

emergil

siplarol

lc44

flupentixol

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of flupenthixol?

A: Molecular weight of flupenthixol is 434.51800.

Q: What are the upstream materials of flupenthixol?

A: Related upstream materials(CAS) of flupenthixol: 103-76-4;28973-34-4.

Q: What is the SMILES notation of flupenthixol?

A: SMILES notation of flupenthixol is OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1.

Q: What is the CAS number of flupenthixol?

A: CAS number of flupenthixol is 2709-56-0.

Q: What is the English name of flupenthixol?

A: The English name of flupenthixol is flupenthixol.

Q: What are the uses of flupenthixol?

A: Main uses of flupenthixol: Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].

Q: What English synonyms does flupenthixol have?

A: English synonyms of flupenthixol: n7009, [3H]-(Z)-Flupentixol, siplaril, fluanxol, Flupentiol, fluxanxol, emergil, siplarol, lc44, flupentixol.

Q: What is the boiling point of flupenthixol?

A: Boiling point of flupenthixol is 554.7ºC at 760mmHg.

Q: What is the molecular formula of flupenthixol?

A: Molecular formula of flupenthixol is C23H25F3N2OS.

Q: What is the polar surface area (PSA) of flupenthixol?

A: Polar surface area (PSA) of flupenthixol is 52.01000.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Flupentixol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Flupentixol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.