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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Flupentixol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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2709-56-0

2709-56-0 structure

2709-56-0 structure

Name: Flupentixol
Chemical Name: flupenthixol
CAS Number: 2709-56-0
Molecular Formula: C₂₃H₂₅F₃N₂OS
Molecular Weight: 434.51800
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-08-01 14:37:24
Modify Date: 2026-06-30 18:51:19
Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].

Name	flupenthixol
Synonyms	flupenthixolQ: What is flupenthixol Q: What is the CAS Number of flupenthixol Q: What is the storage condition of flupenthixol Q: What e the applications of flupenthixol 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethano flupenthixole Aids-115423 lc44 (alpha,beta)-flupenthixol Flupentiol siplil emergil 4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol FLUPENTIOL Flupentixolum Flupentixol alcohol(Flupentixol impurity) Aids115423 2-trifluoromethyl-9-(3-(4-(beta-hydroxyethyl)-1-piperazinyl)propylidene)thio siplol 1-Piperazineethanol,4-[3-[2-(trifluoroMethyl)-9H-thioxanthen-9-ylidene]propyl] CIS(Z)-FLUPENTIXOL 2HCL 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanol 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-1-piperazineethan 1-piperazineethanol,4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propy fluanxol fluxanxol siplarol siplaril flupentixol n7009 1-Piperazineethanol, 4-[(3Z)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl] 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol [3H]-(Z)-Flupentixol

Description	Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor D2 Receptor
References	[1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71. [2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.

Density	1.306g/cm3
Boiling Point	554.7ºC at 760mmHg
Molecular Formula	C₂₃H₂₅F₃N₂OS
Molecular Weight	434.51800
Flash Point	289.3ºC
Exact Mass	434.16400
PSA	52.01000
LogP	4.47750
Index of Refraction	1.607

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL9900000

CHEMICAL NAME :: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl )-

CAS REGISTRY NUMBER :: 2709-56-0

LAST UPDATED :: 199507

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H25-F3-N2-O-S

MOLECULAR WEIGHT :: 434.56

WISWESSER LINE NOTATION :: T C666 BS IYJ IU3- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - changes in motor activity (specific assay) Behavioral - coma

REFERENCE :: DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 15,388,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 367 ug/kg/12D-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - muscle weakness Behavioral - headache

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,93,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2121,1977

Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	TL9900000

103-76-4 structure

103-76-4

28973-34-4 structure

28973-34-4

~%

2709-56-0 structure

2709-56-0

53772-85-3 structure

53772-85-3

Literature: LABORATORIO CHIMICO INTERNAZIONALE S.P.A. Patent: WO2005/37820 A1, 2005 ; Location in patent: Page/Page column 8-9 ;

Precursor 2
103-76-4 28973-34-4
DownStream 0

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