Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Modify Date: 2024-04-02 18:15:45
![Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- Structure](https://image.chemsrc.com/caspic/443/2730-82-7.png)
Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- structure
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Common Name | Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- | ||
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| CAS Number | 2730-82-7 | Molecular Weight | 427.44700 | |
| Density | 1.29g/cm3 | Boiling Point | 786.9ºC at 760mmHg | |
| Molecular Formula | C23H25NO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 429.7ºC | |
Use of Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. |
| Name | N-(4-formyl-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide |
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| Synonym | More Synonyms |
| Description | 4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. |
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| Related Catalog | |
| In Vitro | 4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, HT-29, HCT116 cells Concentration: 0-5 µM Incubation Time: 24 h Result: Inhibited cell growth with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively. |
| References |
| Density | 1.29g/cm3 |
|---|---|
| Boiling Point | 786.9ºC at 760mmHg |
| Molecular Formula | C23H25NO7 |
| Molecular Weight | 427.44700 |
| Flash Point | 429.7ºC |
| Exact Mass | 427.16300 |
| PSA | 100.16000 |
| LogP | 3.07500 |
| Vapour Pressure | 9.93E-25mmHg at 25°C |
| Index of Refraction | 1.589 |
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~99%
Acetamide,N-[(7... CAS#:2730-82-7 |
| Literature: Yasobu, Naoko; Kitajima, Mariko; Kogure, Noriyuki; Shishido, Yoshiyuki; Matsuzaki, Takeshi; Nagaoka, Masato; Takayama, Hiromitsu ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 5 p. 348 - 352 |
| Precursor 2 | |
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| DownStream 1 | |
![Acetamide,N-[5,6,7,9-tetrahydro-4-(hydroxymethyl)-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-,(S)- (9CI) structure](https://image.chemsrc.com/caspic/001/3986-03-6.png)
CAS#:3986-03-6| 1-Formylcolchicin |
| 4-Formylcolchicine |