Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]

• 常用名: Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]
• 英文名: Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]
• CAS号: 2730-82-7
• 分子量: 427.44700
• 密度: 1.29g/cm3
• 沸点: 786.9ºC at 760mmHg
• 分子式: C₂₃H₂₅NO₇
• 熔点: N/A
• 闪点: 429.7ºC

用途

4-甲酰基秋水仙碱是一种有效的抗癌剂。4-甲酰基秋水仙碱对A549、HT-29和HCT116细胞显示出细胞毒性活性,IC50值分别为1.007、0.128和0.054µM[1]。

名称

• 英文名: N-(4-formyl-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide

生物活性

• 描述: 4-甲酰基秋水仙碱是一种有效的抗癌剂。4-甲酰基秋水仙碱对A549、HT-29和HCT116细胞显示出细胞毒性活性,IC50值分别为1.007、0.128和0.054µM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: 4-甲酰基秋水仙碱(化合物7)(0-5µM；24小时)对A549、HT-29和HCT116细胞显示出抗增殖活性,IC50分别为1.007、0.128和0.054µM[1]。细胞活力测定[1]细胞系：A549、HT-29、HCT116细胞浓度：0-5µM培养时间：24小时结果：抑制细胞生长,A549、HT-29、HCC116细胞的IC50分别为1.007、0.128、0.054µM。
• 参考文献:

  [1]. Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52.

物理化学性质

• 密度: 1.29g/cm3
• 沸点: 786.9ºC at 760mmHg
• 分子式: C₂₃H₂₅NO₇
• 分子量: 427.44700
• 闪点: 429.7ºC
• 精确质量: 427.16300
• PSA: 100.16000
• LogP: 3.07500
• InChIKey: JUWAUXATKRGHCK-KRWDZBQOSA-N
• SMILES: COc1c(C=O)c2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2
• 蒸汽压: 9.93E-25mmHg at 25°C
• 折射率: 1.589

靶点实验

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英文别名

• 1-Formylcolchicin
• 4-Formylcolchicine