Pomalidomide-C5-Dovitinib

Modify Date: 2025-08-26 19:54:30

Pomalidomide-C5-Dovitinib structure	Common Name	Pomalidomide-C5-Dovitinib
	CAS Number	2732969-67-2	Molecular Weight	747.77
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₉H₃₈FN₉O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pomalidomide-C5-Dovitinib

Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].

Name	Pomalidomide-C5-Dovitinib

Description	Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
References	[1]. Cao S, et al. Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J Med Chem. 2021;64(22):16497-16511.

Molecular Formula	C₃₉H₃₈FN₉O₆
Molecular Weight	747.77

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pomalidomide-C5-Dovitinib
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Pomalidomide-C5-Dovitinib
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

Pomalidomide-C5-Dovitinib suppliers

Pomalidomide-C5-Dovitinib price

Pomalidomide-C5-Dovitinib

Use of Pomalidomide-C5-Dovitinib

Names

Pomalidomide-C5-Dovitinib Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.