Pomalidomide-C5-Dovitinib

Modify Date: 2024-01-08 13:29:54

Pomalidomide-C5-Dovitinib Structure
Pomalidomide-C5-Dovitinib structure
 Common Name Pomalidomide-C5-Dovitinib
CAS Number 2732969-67-2 Molecular Weight 747.77
Density N/A Boiling Point N/A
Molecular Formula C39H38FN9O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pomalidomide-C5-Dovitinib


Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].

 Names

Name Pomalidomide-C5-Dovitinib

 Pomalidomide-C5-Dovitinib Biological Activity

Description Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].
Related Catalog
References

[1]. Cao S, et al. Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J Med Chem. 2021;64(22):16497-16511.

 Chemical & Physical Properties

Molecular Formula C39H38FN9O6
Molecular Weight 747.77
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Pomalidomide-C5-Dovitinib suppliers

Pomalidomide-C5-Dovitinib price

Related Compounds: More...
Pomalidomide-C6-O-C5-O-C4-COOH
2375774-54-0
Pomalidomide-C9-CO2H
2243000-24-8
Pomalidomide-C7-COOH
2225940-51-0
Pomalidomide-C4-NH2
1957236-34-8
Pomalidomide Impurity 6
1795373-54-4
Pomalidomide-5'-PEG5-C2-COOH
2412056-50-7
Pomalidomide-C4-NH2 hydrochloride
2162120-73-0
Pomalidomide Impurity 1
1001852-14-7
Pomalidomide-d4
1416575-78-4
3-benzyl-2-({[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040670-56-1
3-(4-Chlorophenyl)-4-(3-methylpiperidin-1-yl)cyclobut-3-ene-1,2-dione
931347-91-0
3-benzyl-2-({[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040670-63-0
3-benzyl-2-(((3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)thieno[3,2-d]pyrimidin-4(3H)-one
1040670-70-9
3-benzyl-2-({[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040670-84-5
2-({[3-(2H-1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3-benzyl-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040670-92-5
3-benzyl-2-({[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040671-00-8
3-benzyl-2-({[3-(2,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040671-07-5
3-benzyl-2-({[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
1040671-15-5
3-benzyl-2-(((3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)thieno[3,2-d]pyrimidin-4(3H)-one
1040671-23-5
Chemsrc provides Pomalidomide-C5-Dovitinib(CAS#:2732969-67-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Pomalidomide-C5-Dovitinib are included as well.>> amp version: Pomalidomide-C5-Dovitinib

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved