Pomalidomide-C5-Dovitinib

• 常用名: Pomalidomide-C5-Dovitinib
• 英文名: Pomalidomide-C5-Dovitinib
• CAS号: 2732969-67-2
• 分子量: 747.77
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₉H₃₈FN₉O₆
• 熔点: N/A
• 闪点: N/A

Pomalidomide-C5-Dovitinib用途

Pomalidomide-C5-Dovitinib(化合物2)是一种含有Pomalidomide、Dovitinib并与CRBN连接的PROTAC。Pomalidomide-C5-Dovitinib对FLT3-ITD+AML细胞的抗增殖作用增强。Pomalidomide-C5-Dovitinib以泛素-蛋白酶体依赖的方式诱导FLT3-ITD和KIT蛋白降解,并完全阻断其下游信号通路。波马利多胺-C5-多维替尼具有研究FLT3-ITD+急性髓系白血病的潜力[1]。

Pomalidomide-C5-Dovitinib名称

• 英文名: Pomalidomide-C5-Dovitinib

Pomalidomide-C5-Dovitinib生物活性

• 描述: Pomalidomide-C5-Dovitinib(化合物2)是一种含有Pomalidomide、Dovitinib并与CRBN连接的PROTAC。Pomalidomide-C5-Dovitinib对FLT3-ITD+AML细胞的抗增殖作用增强。Pomalidomide-C5-Dovitinib以泛素-蛋白酶体依赖的方式诱导FLT3-ITD和KIT蛋白降解,并完全阻断其下游信号通路。波马利多胺-C5-多维替尼具有研究FLT3-ITD+急性髓系白血病的潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
  信号通路 >> 蛋白裂解靶向嵌合体 >> E3 Ligase的配体
• 参考文献:

  [1]. Cao S, et al. Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J Med Chem. 2021;64(22):16497-16511.

Pomalidomide-C5-Dovitinib物理化学性质

• 分子式: C₃₉H₃₈FN₉O₆
• 分子量: 747.77
• InChIKey: LOZMISVXTOAAHE-UHFFFAOYSA-N
• SMILES: Nc1c(-c2nc3ccc(N4CCN(C(=O)CCCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cc3[nH]2)c(=O)[nH]c2cccc(F)c12

Pomalidomide-C5-Dovitinib靶点实验

查看更多实验

实验名称：Inhibition of FLT3 ITD mutant (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL4841716

实验名称：Inhibition of FLT3 (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL4841715

实验名称：Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK-8 a... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4841714

实验名称：Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK-8 ... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL4841713

实验名称：Inhibition of HPK1 (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 1 External Id：CHEMBL4841720

实验名称：Inhibition of KIT (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL4841719

实验名称：Inhibition of PDGFRalpha (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Platelet-derived growth factor receptor alpha External Id：CHEMBL4841718

实验名称：Inhibition of FLT3 D835Y mutant (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL4841717

实验名称：Inhibition of GSK3alpha (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Glycogen synthase kinase-3 alpha External Id：CHEMBL4841748

实验名称：Inhibition of ERK1 (unknown origin) at 1000 nM relative to control 来源：ChEMBL 靶标：Mitogen-activated protein kinase 3 External Id：CHEMBL4841747

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