Dim16

Modify Date: 2025-08-29 18:33:11

Dim16 structure	Common Name	Dim16
	CAS Number	2743448-32-8	Molecular Weight	583.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₃₈IN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dim16

Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].

Name	Dim16

Description	Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Metabolic Disease
Target	19 nM (PCSK9)[1]
References	[1]. Lammi C, et al. Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity. J Med Chem. 2023 Jun 22;66(12):7943-7958.

Molecular Formula	C₂₉H₃₈IN₅
Molecular Weight	583.55

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