MTX115325

Modify Date: 2024-01-03 10:59:28

MTX115325 structure	Common Name	MTX115325
	CAS Number	2750895-97-5	Molecular Weight	348.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₆N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MTX115325

MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1].

Name	MTX115325

Description	MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease
Target	IC50: 12 nM (USP30) EC50: 32 nM (TOM20, the outer mitochondrial membrane protein)[1]
References	[1]. Fang TZ et al. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nat Commun. 2023 Nov 13;14(1):7295.

Molecular Formula	C₁₈H₁₆N₆O₂
Molecular Weight	348.36

MTX115325

Use of MTX115325

Names

MTX115325 Biological Activity

Chemical & Physical Properties