Acetophenazine

Modify Date: 2024-01-02 17:08:38

Acetophenazine Structure
Acetophenazine structure
Common Name Acetophenazine
CAS Number 2751-68-0 Molecular Weight 411.56000
Density 1.203g/cm3 Boiling Point 608.7ºC at 760mmHg
Molecular Formula C23H29N3O2S Melting Point N/A
MSDS N/A Flash Point 321.9ºC

 Use of Acetophenazine


Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].

 Names

Name acetophenazine
Synonym More Synonyms

 Acetophenazine Biological Activity

Description Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].
Related Catalog
Target

D2 Receptor

In Vivo Acetophenazine (2.4 mg/kg; i.h.; single dosage) significantly prolongs the time lapse from the first fight to submission and the actual fighting time to submission in mice[3]. Animal Model: C57BL mice (10-12 weeks)[3] Dosage: 2.4 mg/kg Administration: i.h.; single dosage Result: Significantly prolonged the time lapse from the first fight to submission and the actual fighting time to submission.
References

[1]. Azam Bazrafshan, et al. Acetophenazine versus chlorpromazine for schizophrenia. Cochrane Database of Systematic Reviews. 2015, Issue 4.

[2]. Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8.

[3]. KNIGHT WR, HOLTZ JR, SPROGIS GR. ACETOPHENAZINE AND FIGHTING BEHAVIOR IN MICE. Science. 1963 Aug 30;141(3583):830-1.

 Chemical & Physical Properties

Density 1.203g/cm3
Boiling Point 608.7ºC at 760mmHg
Molecular Formula C23H29N3O2S
Molecular Weight 411.56000
Flash Point 321.9ºC
Exact Mass 411.19800
PSA 72.32000
LogP 3.43270
Vapour Pressure 7.83E-16mmHg at 25°C
Index of Refraction 1.615

 Safety Information

Hazard Codes Xn

 Synonyms

1-(10-{3-[4-(2-hydroxy-ethyl)-piperazino]-propyl}-phenothiazin-2-yl)-ethanone
Acetophenazinum [INN-Latin]
1-(10-{3-[4-(2-Hydroxy-aethyl)-piperazino]-propyl}-phenothiazin-2-yl)-aethanon
10-<3-(1-(2-Hydroxy-aethyl)-piperazinyl-(4))-propyl>-2-acetyl-phenothiazin
2-acetyl-10-(-3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl)phenothiazine
Acetophenazinum
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone
Acetophenazina [INN-Spanish]
ACETOPHENAZINE
Acephenazinum
Tindal
1-(10-{3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-propyl}-10H-phenothiazin-2-yl)-ethanone
Acetophenazine [INN]
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