ACETOPHENAZINE

Modify Date: 2024-01-02 14:13:55

ACETOPHENAZINE Structure
ACETOPHENAZINE structure
Common Name ACETOPHENAZINE
CAS Number 5714-00-1 Molecular Weight 527.63200
Density N/A Boiling Point 608.7ºC at 760 mmHg
Molecular Formula C27H33N3O6S Melting Point 167-168.5°
MSDS N/A Flash Point 321.9ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of ACETOPHENAZINE


Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression[1].

 Names

Name acetophenazine dimaleate
Synonym More Synonyms

 ACETOPHENAZINE Biological Activity

Description Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression[1].
Related Catalog
References

[1]. Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8.

 Chemical & Physical Properties

Boiling Point 608.7ºC at 760 mmHg
Melting Point 167-168.5°
Molecular Formula C27H33N3O6S
Molecular Weight 527.63200
Flash Point 321.9ºC
Exact Mass 527.20900
PSA 146.92000
LogP 3.14450

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OB4180000
CHEMICAL NAME :
Ketone, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenot hiazin-2-yl methyl, dimaleate
CAS REGISTRY NUMBER :
5714-00-1
LAST UPDATED :
199706
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C23-H29-N3-O2-S.2C4-H4-O4
MOLECULAR WEIGHT :
643.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 14,250,1956 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
415 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01100
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS OB4180000

 Articles6

More Articles
[CLINICAL OBSERVATIONS ON THE ACTION OF TINDAL IN PSYCHIATRIC TREATMENT].

Neurol. Neurochir. Psychiatr. Pol. 14 , 683-6, (1964)

Synergism of combined lithium-neuroleptic therapy: a double-blind, placebo-controlled case study.

Am. J. Psychiatry 138(1) , 81-3, (1981)

The authors describe a longitudinal, placebo-controlled study of the response to drug treatment of a 62-year-old schizoaffective patient hospitalized for 40 years. While neither lithium nor a neurolep...

HEMODYNAMIC EFFECTS OF IMIPRAMINE, ACETOPHENAZINE, AND TRIFLUOPERAZINE IN GERIATRIC PSYCHIATRY.

Dis. Nerv. Syst. 26 , 427-9, (1965)

 Synonyms

sch6673
acetophenazinemaleate
Ethanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-, (Z) 2-butenedioate (1_2) (salt)
Acetophazine maleate
ACETOPHENZAINEMALEATE
tindal
Acetophenazine dimaleate
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