Radotinib-d6

Modify Date: 2023-01-17 16:27:56

Radotinib-d6 structure	Common Name	Radotinib-d6
	CAS Number	2754051-83-5	Molecular Weight	536.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₁₅D₆F₃N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Radotinib-d6

Radotinib-d6 is deuterium labeled Radotinib.

Name	Radotinib-d6

Description	Radotinib-d6 is deuterium labeled Radotinib.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kim SH, et al. Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors. Haematologica. 2014 Jul;99(7):1191-6.

Molecular Formula	C₂₇H₁₅D₆F₃N₈O
Molecular Weight	536.54