1-Aminocyclohexanecarboxylic acid

Modify Date: 2024-01-02 21:25:34

1-Aminocyclohexanecarboxylic acid Structure
1-Aminocyclohexanecarboxylic acid structure
Common Name 1-Aminocyclohexanecarboxylic acid
CAS Number 2756-85-6 Molecular Weight 143.184
Density 1.1±0.1 g/cm3 Boiling Point 272.3±23.0 °C at 760 mmHg
Molecular Formula C7H13NO2 Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point 118.5±22.6 °C

 Names

Name 1-amino-1-cyclohexanecarboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 272.3±23.0 °C at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C7H13NO2
Molecular Weight 143.184
Flash Point 118.5±22.6 °C
Exact Mass 143.094635
PSA 63.32000
LogP 0.51
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.509
Storage condition Store at RT.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU8393000
CHEMICAL NAME :
Cyclohexanecarboxylic acid, 1-amino-
CAS REGISTRY NUMBER :
2756-85-6
BEILSTEIN REFERENCE NO. :
2355692
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H13-N-O2
MOLECULAR WEIGHT :
143.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 5,108,1960

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S22-S24/25-S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GU8393000
HS Code 2922499990

 Synthetic Route

~73%

1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Stoyanov, Neyko; Marinov, Marin Acta Chimica Slovenica, 2012 , vol. 59, # 3 p. 680 - 685,6 Title/Abstract Full Text Show Details Stoyanov, Neyko; Marinov, Marin Acta Chimica Slovenica, 2012 , vol. 59, # 3 p. 680 - 685

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Kidani; Yoshinori Patent: US4255347 A1, 1981 ;

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Wang, Boyuan; Zhang, Wei; Zhang, Leilei; Du, Da-Ming; Liu, Gang; Xu, Jiaxi European Journal of Organic Chemistry, 2008 , # 2 p. 350 - 355

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Aboul-Enein, M. N.; El-Azzouny, A. A.; Abdallah, N. A.; Makhlouf, A. A. Egyptian Journal of Chemistry, 1991 , vol. 34, # 6 p. 549 - 558

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Krzyzanowska,B.; Stec,W.J. Synthesis, 1978 , p. 521 - 524

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Krzyzanowska,B.; Stec,W.J. Synthesis, 1978 , p. 521 - 524

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Bucherer; Brandt Journal fuer Praktische Chemie (Leipzig), 1934 , vol. <2> 140, p. 129,135, 150

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Maurs, Michele; Acher, Francine; Azerad, Robert Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 22 - 26

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1-Aminocyclohexanecarboxylic acid Structure

1-Aminocyclohex...

CAS#:2756-85-6

Literature: Krzyzanowska,B.; Stec,W.J. Synthesis, 1978 , p. 521 - 524

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles14

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J. Med. Chem. 52 , 5093-107, (2009)

Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid...

Application of 1-aminocyclohexane carboxylic acid to protein nanostructure computer design.

J. Chem. Inf. Model. 48(2) , 333-43, (2008)

Conformationally restricted amino acids are promising candidates to serve as basic pieces in redesigned protein motifs which constitute the basic modules in synthetic nanoconstructs. Here we study the...

Influence of 1-aminocyclohexane-1-carboxylic acid in position 2 or 3 of AVP and its analogues on their pharmacological properties.

J. Pept. Res. 62(2) , 70-7, (2003)

In this study we describe the synthesis and some pharmacological properties of seven new analogues of arginine vasopressin (AVP) substituted in position 2 or 3 with 1-aminocyclohexane-1-carboxylic aci...

 Synonyms

1-amino-cyclohexane-1-carboxylic acid
Cyclohexanecarboxylic acid,1-amino
a-Aminocyclohexanecarboxylic acid
1-Aminocyclohexanecarboxylic acid
1-amino-1-cyclo-hexanecarboxylic acid
1-amino-1-cyclohexane carboxylic acid
Homocycloleucine
1-aminocyclohexane-1-carboxylic acid
1-amino-1-cyclohexylcarboxylic acid
1-amino-1-cyclohexanecarboxylic acid
MFCD00001487
Cyclohexanecarboxylic acid, 1-amino-
1-Amino-1-CyclohexanecarboxylicAcid
EINECS 220-411-0