GLP-2(3-33)

Modify Date: 2024-01-01 19:31:01

GLP-2(3-33) structure	Common Name	GLP-2(3-33)
	CAS Number	275801-62-2	Molecular Weight	3557.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅₆H₂₄₂N₄₀O₅₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GLP-2(3-33)

GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM)[1][2].

Name	GLP-2(3-33)

Description	GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM)[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
In Vitro	GLP-2 is secreted as a 33-amino acid peptide, but is rapidly degraded at an N-terminus site to GLP-2(3-33) in circulation, in large part, by dipeptidylpeptidase IV (DPPIV). GLP-2 (3-33) acts as a partial agonist with potential competitive antagonistic properties on the GLP-2 receptor. In the GLP-2 receptor-binding assay, the binding IC50 for GLP-2 1–33 was 3.1 nM, and it was 41 nM for GLP-2 3-33. Thus, GLP-2 3–33 had 7.5% binding affinity compared to GLP-2 1-33[1].
In Vivo	GLP-2(3-33) (60 ng; once a day i.p. for 4 weeks) increases dyslipidemia and hepatic lipid accumulation in HFD-fed mice[2]. Animal Model: Male C57BL/6J (B6) mice (HFD)[2] Dosage: 60 ng Administration: Once a day i.p. for 4 weeks Result: Significantly affected plasma lipids; Showed increase of triglycerides and cholesterol and reduction of HDL; Significantly increased plasma ALT and AST and intrahepatic lipid concentration.
References	[1]. Thulesen J, Knudsen LB, Hartmann B, Hastrup S, Kissow H, Jeppesen PB, Ørskov C, Holst JJ, Poulsen SS. The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist. Regul Pept. 2002 Jan 15;103(1):9-15. [2]. Baldassano S, et al. Influence of endogenous glucagon-like peptide-2 on lipid disorders in mice fed a high-fat diet. Endocr Res. 2016 Nov;41(4):317-324.

Molecular Formula	C₁₅₆H₂₄₂N₄₀O₅₃S
Molecular Weight	3557.89

DC Chemicals Limited
China
Product Name: GLP-2(3-33)
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Zhejiang Hangyu API Co., Ltd
China
Product Name: GLP-2(3-33)
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Purity: 99.0%
Stocking Period: 1 Day
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GLP-2(3-33)

Use of GLP-2(3-33)

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GLP-2(3-33) Biological Activity

Chemical & Physical Properties