275801-62-2
275801-62-2 structure
- Name: GLP-2(3-33)
- Chemical Name: GLP-2(3-33)
- CAS Number: 275801-62-2
- Molecular Formula: C156H242N40O53S
- Molecular Weight: 3557.89
- Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
- Create Date: 2020-10-18 07:12:06
- Modify Date: 2024-01-01 19:31:01
-
GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM)[1][2].
| Name | GLP-2(3-33) |
|---|
| Description | GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM)[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | GLP-2 is secreted as a 33-amino acid peptide, but is rapidly degraded at an N-terminus site to GLP-2(3-33) in circulation, in large part, by dipeptidylpeptidase IV (DPPIV). GLP-2 (3-33) acts as a partial agonist with potential competitive antagonistic properties on the GLP-2 receptor. In the GLP-2 receptor-binding assay, the binding IC50 for GLP-2 1–33 was 3.1 nM, and it was 41 nM for GLP-2 3-33. Thus, GLP-2 3–33 had 7.5% binding affinity compared to GLP-2 1-33[1]. |
| In Vivo | GLP-2(3-33) (60 ng; once a day i.p. for 4 weeks) increases dyslipidemia and hepatic lipid accumulation in HFD-fed mice[2]. Animal Model: Male C57BL/6J (B6) mice (HFD)[2] Dosage: 60 ng Administration: Once a day i.p. for 4 weeks Result: Significantly affected plasma lipids; Showed increase of triglycerides and cholesterol and reduction of HDL; Significantly increased plasma ALT and AST and intrahepatic lipid concentration. |
| References |
| Molecular Formula | C156H242N40O53S |
|---|---|
| Molecular Weight | 3557.89 |