Trk-IN-9

Modify Date: 2024-01-22 18:24:43

Trk-IN-9 Structure
Trk-IN-9 structure
Common Name Trk-IN-9
CAS Number 2758623-12-8 Molecular Weight 454.93
Density N/A Boiling Point N/A
Molecular Formula C23H24ClFN6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Trk-IN-9


Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers[1].

 Names

Name Trk-IN-9

 Trk-IN-9 Biological Activity

Description Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers[1].
Related Catalog
References

[1]. Wu T, et al. Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold. Eur J Med Chem. 2022;230:114096.

 Chemical & Physical Properties

Molecular Formula C23H24ClFN6O
Molecular Weight 454.93
Storage condition -20°C
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