Skp2 inhibitor 1

Modify Date: 2025-08-26 23:36:53

Skp2 inhibitor 1 Structure
Skp2 inhibitor 1 structure
Common Name Skp2 inhibitor 1
CAS Number 2760612-63-1 Molecular Weight 406.91
Density N/A Boiling Point N/A
Molecular Formula C23H23ClN4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Skp2 inhibitor 1


Skp2 inhibitor 1 (compound 14i) is a potent and selective Skp2 inhibitor against the Skp2-Cks1 interaction with an IC50 of 2.8 μM. Skp inhibitor 1 exhibits anticancer activity[1].

 Names

Name Skp2 inhibitor 1

 Skp2 inhibitor 1 Biological Activity

Description Skp2 inhibitor 1 (compound 14i) is a potent and selective Skp2 inhibitor against the Skp2-Cks1 interaction with an IC50 of 2.8 μM. Skp inhibitor 1 exhibits anticancer activity[1].
Related Catalog
Target

Growth arrest-specific protein 6(Gas6)-Cell Cyclin Kinase Subunit 1(Cks1) [1]IC50:2.8 μM(Growth arrest-specific protein 6,Gas6; Cell Cyclin Kinase Subunit 1,Cks1)[1]

References

[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.  

 Chemical & Physical Properties

Molecular Formula C23H23ClN4O
Molecular Weight 406.91
InChIKey MKWLNXUIWPRODH-UHFFFAOYSA-N
SMILES O=C(CCl)NC1CCN(c2cnc(-c3ccccc3)c(-c3ccccc3)n2)CC1
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