Skp2 inhibitor 2

Modify Date: 2025-08-25 17:42:08

Skp2 inhibitor 2 structure	Common Name	Skp2 inhibitor 2
	CAS Number	2760612-77-7	Molecular Weight	428.57
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₂N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Skp2 inhibitor 2

Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].

Name	Skp2 inhibitor 2

Description	Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	cullin-RING ligases[1]
References	[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.

Molecular Formula	C₂₇H₃₂N₄O
Molecular Weight	428.57

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Skp2 inhibitor 2

Use of Skp2 inhibitor 2

Names

Skp2 inhibitor 2 Biological Activity

Chemical & Physical Properties

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