Skp2 inhibitor 2

Modify Date: 2024-01-17 11:30:04

Skp2 inhibitor 2 Structure
Skp2 inhibitor 2 structure
Common Name Skp2 inhibitor 2
CAS Number 2760612-77-7 Molecular Weight 428.57
Density N/A Boiling Point N/A
Molecular Formula C27H32N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Skp2 inhibitor 2


Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].

 Names

Name Skp2 inhibitor 2

 Skp2 inhibitor 2 Biological Activity

Description Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].
Related Catalog
Target

cullin-RING ligases[1]

References

[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.  

 Chemical & Physical Properties

Molecular Formula C27H32N4O
Molecular Weight 428.57
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